Increase in Over-the-Counter Drug Abuse Among Teens Raises Health Concerns

There is a growing concern about over-the-counter medication abuse among teenagers in the United States. Recent records from America’s Poison Centers, which comprise 53 centers nationwide, highlight a significant rise in diphenhydramine abuse among teens aged 13 to 19.

Diphenhydramine Abuse on the Rise

Diphenhydramine, often included in allergy and sleep aids like Benadryl and Zzzquil, has seen increased misuse. From 2024 to 2025, there was a 5.1% rise in overall substance exposure among teenagers. Notably, diphenhydramine cases surged from 10,068 to 13,284, marking a 32% increase. In 2026, 13% of these cases were linked to deliberate abuse, up from 7.3% in 2020.

Health Risks and Warning Signs

The advisory warns that improper or excessive intake of diphenhydramine can impact the brain and heart, leading to severe or even life-threatening effects. Symptoms of poisoning can include drowsiness, rapid heart rate, nausea, vomiting, hallucinations, seizures, irregular heart rhythm, and loss of consciousness.

America’s Poison Centers recommend securing all medications out of reach of children and teens and strictly following label instructions.

Expert and Manufacturer Responses

Benadryl manufacturer Kenvue emphasizes the importance of halting the social media trend that encourages the misuse of diphenhydramine products. A spokesperson stated that public safety is their top priority, and they are working with social media platforms to eliminate harmful content.

Mary Leonard, Senior Vice President of Communications and Public Affairs for the Consumer Healthcare Products Association, underscores the dangers of using over-the-counter medicines for recreation.

Preventive Measures

Kenvue advises the following steps to prevent misuse:

• Report dangerous content on social media platforms.
• Store over-the-counter medicines out of children’s reach, ideally in locked cabinets.
• Follow label instructions closely and educate children on safe medicine use.

For additional safety information, individuals can visit Benadryl.com or consult healthcare professionals with any questions.